You can use almost any graphics or creative printing program to design iron on transfer artwork. Ideally the program will have an option to flip or reverse the image for transfer printing or you can manually flip the image in the document. However, there are some t-shirt design software programs specifically for creating personalized t-shirt designs and similar iron on transfer craft projects. These programs are for the Windows platform.
1. Art Explosion T-Shirt Factory Deluxe
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Thousands of ready-made designs or create your own with over 28,000 clip art images. This Nova Development package comes with a t-shirt, transfer paper, and bonus photo-editing and creativity software. The T-Shirt Factory also includes a Perfectshirt guarantee. An expansion pack is available with more paper and more clip art and project ideas. 
2. Hanes T-ShirtMaker Deluxe
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Get ready-made t-shirt designs, thousands of clip art images, photos, fonts, easy to use software, a white t-shirt, a blank mousepad, iron-on transfer paper, and an Oops! proof guarantee. Hanes2U
3. Hanes T-ShirtMaker Lite
This lite version of their T-ShirtMaker product is available for a free download but you have to join the Hanes2u community (it's free). If your needs are basic, this may be all you need.4. Create Your Own T-Shirts 2nd Edition
Create Your Own T-Shirts from Focus Multimedia
This Focus Multimedia (a UK-based publisher) software is also available from Serif Extra!. Windows Vista compatible, it's an inexpensive program that offers 200+ templates and 1,000 clip art images. You can also import your own photos to put on a t-shirt. There are some basic photo editing tools (red eye and scratch removal) and a step-by-step wizard to guide you through your t-shirt design. It creates mirror images for printing on transfer paper.
